Home > Areas We Serve
Native Nations Cannabis opened its doors in Flandreau on July 1, 2021, as the first cannabis operation in South Dakota. We sit on the sovereign land of the Flandreau Santee Sioux Tribe, and the Tribe owns and operates every step, from the grow room to the counter.
Medical cannabis patients come to us from across Moody, Minnehaha, Brookings and Lake counties. Below you’ll find the towns we serve, how long the drive takes from each one, and how to reach our team before you head out.
Native Nations Cannabis belongs to the Flandreau Santee Sioux Tribe. A portion of our proceeds goes back into education, healthcare and other community initiatives.
We’re a fully vertically integrated operation. Most of the flower, pre-rolls, vapes, concentrates and edibles on our shelves carry the Native Nations Cannabis name.
We welcomed our first patients a full year before any state-licensed facility opened, and we’ve been serving the region ever since.
We’re open Monday through Saturday from 9am to 8pm and Sunday from 10am to 6pm, so a weekend trip works as well as a weekday one.
Build your order on our online menu, then pick it up and pay at the counter when you arrive. We accept cash and debit.
The Flandreau Santee Sioux Tribe is made up mostly of descendants of the Mdewakantonwan, part of the Isanti division of the Great Sioux Nation. Tribal members call themselves Dakota, a word that means friend or ally.
The reservation covers about 2,500 acres along and near the Big Sioux River in Moody County, in the gently rolling country known as the Prairie Coteau. Because the Tribe is sovereign, it was able to open Native Nations Cannabis under its own regulatory authority, a year before South Dakota licensed its first facility.
That history shapes how we work today. Native Nations is a mission-driven brand, and the business exists to support Indigenous communities, empower Native entrepreneurs and help revitalize Indigenous culture.
Check the menu. Browse our online menu and add what you want to your bag.
Bring your card and ID. On your first visit, bring your medical cannabis card and a valid photo ID. Purchases require a Flandreau Santee Sioux Tribe (FSST) medical card, and your existing card can be mirrored to one at no additional cost.
Pick up in Flandreau. Head to 1301 S Veterans St Ste 1, collect your order at the counter and pay with cash or debit.
If you have questions before you drive in, call us at (605) 573-4266.
Flandreau is the Moody County seat, set along the Big Sioux River and home to the Flandreau Indian School, a federal boarding school since 1893. Our store is at 1301 S Veterans St Ste 1, on the same road as Royal River Casino & Hotel.
South Dakota’s largest city is about 41 minutes away. Take I-29 north to the SD-34 exit and head east toward Flandreau.
Home to South Dakota State University, Brookings is a 29-minute drive south by way of I-29 and SD-32.
Dell Rapids has no dispensary of its own, and our counter is about 24 minutes away on 474th Avenue and SD-34.
The Lake County seat and home of Dakota State University, Madison sits 32 minutes west of us on SD-34.
Our menu is built around cannabis we grow and make ourselves, with a handful of outside brands in the accessories case.
The easiest way to visit from out of town is to place your order on our online menu before you leave. When you get to Flandreau, your order will be waiting at the counter.
Native Nations serves registered medical cannabis patients. We accept state-issued and tribal medical cannabis cards, including cards issued outside South Dakota. To make a purchase, you’ll need a Flandreau Santee Sioux Tribe (FSST) medical card, and your existing card can be mirrored to an FSST card at no additional cost.
First-time patients should bring their medical cannabis card and a valid photo ID. If you’re a returning patient with a question about identification, call us at (605) 573-4266 before your visit. We accept cash and debit at the counter.
Native Nations Cannabis Dispensary
1301 S Veterans St Ste 1, Flandreau, SD 57028
(605) 573-4266
Monday to Saturday, 9am to 8pm. Sunday, 10am to 6pm.
Wheelchair-accessible entrance.
Wherever you’re coming from, the route ends on South Veterans Street in Flandreau. Check the menu, place your order and we’ll see you at the counter.
Get exclusive product drops, cultural insights, and community updates
