Home > Areas We Serve > Brookings, SD
Brookings is a college town at heart, home to South Dakota State University and more than 25,000 residents. Head 28 miles south and you’ll reach Native Nations Cannabis in Flandreau, a 29-minute drive down I-29 and SD-32.
We’re the medical dispensary owned and operated by the Flandreau Santee Sioux Tribe, and our shelves are stocked with cannabis we grow and make ourselves. From either Brookings zip code, 57006 or 57007, it’s an easy afternoon trip, and you can order online before you leave.
There are dispensaries in Brookings, so a trip south comes down to what makes Native Nations different.
Native Nations is a fully vertically integrated operation on the Flandreau Santee Sioux Tribe’s land. The same tribal business that cultivates our plants runs the counter where you pick them up.
A portion of what we earn funds education, healthcare and other initiatives, and it supports Native entrepreneurs and economic growth in the region.
Native Nations opened to the public on July 1, 2021, the first cannabis operation anywhere in South Dakota. Our story explains how tribal sovereignty made that possible.
With evening hours until 8pm six days a week, a drive after a shift or a lecture still gets you here with time to spare.
From town, get on I-29 South off 6th Street. Stay on the interstate for about 18 miles and take exit 114 for SD-32 East. Follow SD-32 East for roughly 8 miles into Flandreau, where it meets South Veterans Street, and you’re there.
The whole trip runs about 28 miles and 29 minutes, and there’s an accessible parking lot and entrance when you arrive.
Native Nations Cannabis Dispensary
1301 S Veterans St Ste 1, Flandreau, SD 57028
(605) 573-4266
Monday to Saturday, 9am to 8pm. Sunday, 10am to 6pm.
Our house brand covers most of the store. Flower comes by the eighth, half ounce or ounce, and the pre-roll shelf has singles, five-packs and infused options. Vape fans will find a deep list of 1g cartridges, and concentrate shoppers can choose from cured batter, sugar, crumble and RSO.
If you’d rather not smoke, look at our gummies, caramels, sugar-free suckers and 1:1 tinctures, plus topicals. Accessories and Native Nations apparel round out the case. Browse it all online, add what you want to your bag, and check the specials page for this week’s deals before you head south.
Brookings packs a lot into a small city. A few places worth a stop:
SDSU is the state’s largest university and its land-grant school, with a fall 2025 enrollment of 12,139 students from 48 states and 78 countries.
Run by SDSU, McCrory Gardens pairs 25 acres of formal display gardens with the South Dakota State Arboretum, which tests trees and shrubs that can handle a prairie winter.
Admission is free at the South Dakota Art Museum, whose collections include works by Harvey Dunn and Oscar Howe.
On the southern edge of town at 22nd Avenue South and 32nd Street South, Dakota Nature Park and the Larson Nature Center offer trails, fishing and paddling all year.
Families with kids in tow know the Children’s Museum of South Dakota, right in Brookings.
City services and events are on the City of Brookings website.
About 29 minutes. The fastest route is I-29 South to exit 114, then SD-32 East into Flandreau, roughly 28 miles in all.
Yes, Brookings has medical dispensaries. Native Nations is the tribally owned option a short drive south, with a menu built around our own house brand.
On your first visit, bring your medical cannabis card and a valid photo ID, plus cash or a debit card for payment. We accept state, tribal and out-of-state medical cards, and your card can be mirrored at no additional cost to the Flandreau Santee Sioux Tribe (FSST) medical card required for purchases.
Yes. Add items to your bag on our online menu, place your order, and pay with cash or debit when you collect it at the counter in Flandreau.
Yes. We’re open Saturday from 9am to 8pm and Sunday from 10am to 6pm, along with weekdays from 9am to 8pm.
No. Only medical cannabis is legal in South Dakota, and we serve medical cannabis patients.
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Twenty-nine minutes down the road, a Tribe-run dispensary is ready for you. Start your order online and we’ll see you in Flandreau.
