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Sioux Falls is the biggest city in South Dakota, and for its medical cannabis patients we’re an easy run up I-29. Native Nations Cannabis is in Flandreau, about 42 miles north of downtown, and the trip takes roughly 41 minutes in usual traffic.
Whether your address ends in 57104 or 57110, you’ll find a dispensary owned and operated by the Flandreau Santee Sioux Tribe, stocked with cannabis we grow and make ourselves. Place your order online before you leave town and it will be ready at the counter when you arrive.
Most of the drive is interstate. Head north on I-29 for about 28 miles and take the SD-34 exit toward Madison. Turn right onto SD-34 East and follow it for a little over 8 miles, then turn left onto 480th Avenue. The store is about 2 miles up on your right.
All in, it’s about 42 miles and 41 minutes from the center of Sioux Falls. The store has a wheelchair-accessible entrance.
Native Nations Cannabis Dispensary
1301 S Veterans St Ste 1, Flandreau, SD 57028
(605) 573-4266
Monday to Saturday, 9am to 8pm. Sunday, 10am to 6pm.
Nearly everything on our shelves is grown and made under the Native Nations Cannabis name. That includes flower in eighths, half ounces and full ounces, single and five-pack pre-rolls, infused pre-rolls, 1g vape cartridges, and cured concentrates like batter, sugar and crumble. The edibles case holds gummies, caramels, sugar-free suckers and 1:1 tinctures, and we carry topicals, accessories and branded apparel too.
Stock can change from day to day, so check the menu the morning of your trip. Weekly deals are posted on our specials page.
Sioux Falls has dispensaries of its own, so we know a 40-minute drive has to be worth it. Here’s what sets a visit to Flandreau apart.
The Tribe owns and runs Native Nations from seed to sale. When you shop with us, part of what you spend supports education, healthcare and other programs for the community.
Our flower, vapes, pre-rolls, concentrates and edibles are made here in Flandreau. Shopping at the source means you see the full lineup in one place.
We opened on July 1, 2021, a year before the first state-licensed dispensary in South Dakota. That history is part of the Tribe’s story, and you can read more of it on our About page.
The route is almost all I-29, and ordering ahead means you can be back on the road shortly after you walk in.
A trip to Flandreau can fit around a day in the city. A few Sioux Falls favorites:
The city’s namesake waterfalls run through Falls Park, where you can climb the observation tower, stop in at the visitor center and walk past the ruins of the Queen Bee Mill.
The Big Sioux River Recreation Trail has a main loop of about 19 miles that follows the Big Sioux River around the city.
Downtown’s SculptureWalk fills downtown streets with a new exhibit of outdoor sculpture every year, and 2026 marks its 23rd season.
The Washington Pavilion brings performing arts, visual arts and the Kirby Science Discovery Center together in one historic downtown building.
The Great Plains Zoo shows off animals from seven continents, from red wolves and lions to rhinos, penguins and giraffes.
For city news and events, visit the City of Sioux Falls.
Join our newsletter for product drops, cultural insights and community updates from Flandreau. It’s a simple way to know what’s new before you make the trip from Sioux Falls.
Our store in Flandreau is about 42 miles from the center of Sioux Falls. The drive takes roughly 41 minutes on I-29 North and SD-34 East.
Yes, Sioux Falls has medical dispensaries of its own. Native Nations is about 40 minutes north in Flandreau, and it’s owned and operated by the Flandreau Santee Sioux Tribe.
Yes. Native Nations serves registered medical cannabis patients, and we accept state, tribal and out-of-state medical cards. Purchases require a Flandreau Santee Sioux Tribe (FSST) medical card, and your existing card can be mirrored to one at no additional cost. On your first visit, bring your medical card and a valid photo ID.
Yes. Build your order on our online menu before you leave, then pick it up and pay with cash or debit when you arrive in Flandreau.
We’re open Monday through Saturday from 9am to 8pm and Sunday from 10am to 6pm.
No. South Dakota allows medical cannabis only, and Native Nations serves medical patients.
Park in the lot at 1301 S Veterans St Ste 1. It’s wheelchair accessible, and so is the store entrance.
When you’re ready, check what’s in stock, place your order and point the car toward Flandreau. We’ll have it waiting.
